Clinically confirmed cases of arsenicosis were diagnosed on the basis of WHO criteria (WHO 2005) in 123 cases out of 707 participants (17.4%) examined during base line study. Amongst the 123 patients seen, only pigmentation of skin was found in 62 (50.4%) and both pigmentation and keratosis were seen in 61(49.6%) cases. People having low nutritional status (BMI <20) were found to have more arsenical skin lesion compared to people with better nutritional status (BMI >20). In regard to systemic manifestation, pallor (38.2%), weakness (24.4%), conjunctival congestion (21.14%), cough (19.5%), claudication (13.8%) and paraesthesia (10.5%) were present in a good number of cases having skin lesions of cases of arsenicosis in the baseline study.
No new case of arsenicosis was found amongst the people examined at the end of 12 months of drinking arsenic free water. There was significant improvement of arsenical skin lesion among the cases studied. Clearance of pigmentation was noticed in 22 (19.64%) while 6 cases of severe pigmentation became moderate. Clearance of keratosis was observed in 8 (14.28%) out of 56 cases of base line study. Though severe keratosis was observed in 4 cases during baseline study no case of severe keratosis was seen at the end of 12 months. There was also improvement of systemic manifestation in good number of arsenicosis cases. This improvement was significant in regard to symptoms like weakness, cough, conjunctival congestion and chronic diarrhea. There was some improvement of other symptoms like pallor, dyspnoea, splenomegaly and claudication also, but these were not statistically significant.
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